The KLF8 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to KLF8. This antibody recognizes Human antigen. The KLF8 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G1 phase as a downstream target of focal adhesion kinase (FAK).
Subunit Structure: Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.
Post-translational Modifications: Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G1 phase. Has no effect on subcellular location.
Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family